The church was built together with the adjacent hospital complex in 1421 from the foundation of the prince bishop Jan Kropidłoa, although in 1400 prince Władysław II of Opole confirmed the foundation of the merchant Kuncze Cromer regarding the hospital dedicated to St. Alexius, which supposedly could accommodate eight patients. The brick hospital of Jan Kropidło (which could accommodate seventeen patients) burned down in 1615. It was rebuilt, but again damaged in 1682 or 1684. In 1691, the Gothic chapel was transformed, giving it a baroque decor (among others, the windows were transformed). In 1739 the hospital burned down completely. It was rebuilt in a changed, more modest form in the years 1857-1861, and in the years 1865-1866 a completely new one was built, enlarged in 1912.
The hospital and the chapel were founded at the Oder Gate, in the north-west part of the city, near the river and city walls within which it were located. It had dimensions of about 54 x 7 meters and about 5 rooms and four chambers (that was the number before the fire of 1739, it is not known whether a similar layout functioned in the Middle Ages).
The chapel was founded on a rectangular plan with a presbytery three sides ended on the east side. The building was reinforced with buttresses and covered with a gable roof, bent over the presbytery. The entrance was placed in the west facade, while the interior was originally lit by pointed windows. The nave and presbytery were crowned with a cross-rib vault based on modestly profiled corbels, and the basement located below was covered with a barrel vault.
Popłonyk U., Opole, Warszawa 1970.